289 research outputs found
Transition metal complexes partnered with the highly alkylated carborane anion, [1-H-CLOSO-CB11Me11]
Three-coordinate iron(II) expanded ring N-heterocyclic carbene complexes
A sterically demanding seven-membered expanded ring N-heterocyclic carbene (NHC) ligand allows access to rare examples of three-coordinate iron(II)-NHC complexes incorporating only halide coligands of the general formula [Fe(NHC)X 2 ] (NHC = 7-DiPP; X = Br (1) Cl (2)). Reducing the steric influence of the ancillary NHC ligand through modulation of the N-aryl substituents leads to either four- or three-coordinate complexes of the general formula [Fe(NHC)Br 2 (THF)] (3) or [Fe(NHC)Br 2 ] (4) (NHC = 7-Mes), dependent upon the solvent of recrystallization. The further reduction of NHC steric influence results in four-coordinate geometries at iron in the form of the dimeric species [Fe(NHC)Br(Îź-Br)] 2 (5) or [Fe(NHC)Br 2 (THF)] (6) (NHC = SDiPP), again dependent upon the solvent of recrystallization. Compounds 1-6 have been analyzed by 1 H NMR spectroscopy, X-ray crystallography, elemental microanalysis, MĂśssbauer spectroscopy (for 1 and 3-5), and Evans method magnetic susceptibility. In addition to these measurements the three-coordinate species 1 and 4 have been further analyzed by SQUID magnetometry and CASSCF calculations, which show significant magnetic anisotropy that is extremely sensitive to the coordination geometry
Developing organoboranes as phase transfer catalysts for nucleophilic fluorination using CsF
Despite the general high fluorophilicity of boron, organoboranes such as BEt(3) and 3,5-(CF(3))(2)C(6)H(3)âBPin are shown herein for the first time, to our knowledge, to be effective (solid to solution) phase-transfer catalysts for the fluorination of certain organohalides with CsF. Significant (up to 30% e.e.) chiral induction during nucleophilic fluorination to form β-fluoroamines using oxazaborolidine (pre)catalysts and CsF also can be achieved. Screening different boranes revealed a correlation between calculated fluoride affinity of the borane and nucleophilic fluorination reactivity, with sufficient fluoride affinity required for boranes to react with CsF and form Cs[fluoroborate] salts, but too high a fluoride affinity leading to fluoroborates that are poor at transferring fluoride to an electrophile. Fluoride affinity is only one component controlling reactivity in this context; effective fluorination also is dependent on the ligation of Cs(+) which effects both the phase transfer of CsF and the magnitude of the [CsâŻF-BR(3)] interaction and thus the BâF bond strength. Effective ligation of Cs(+) (e.g. by [2.2.2]-cryptand) facilitates phase transfer of CsF by the borane but also weakens the CsâŻFâB interaction which in turn strengthens the BâF bond â thus disfavouring fluoride transfer to an electrophile. Combined, these findings indicate that optimal borane mediated fluorination occurs using robust (to the fluorination conditions) boranes with fluoride affinity of ca. 105 kJ mol(â1) (relative to Me(3)Si(+)) under conditions where a signficant CsâŻFâB interaction persists
The synthesis of brominated-boron-doped PAHs by alkyne 1,1-bromoboration: mechanistic and functionalisation studies
The research leading to these results has received funding from the European Research Council under the Horizon 2020 Research and Innovation Program (Grant no. 769599), the Leverhulme Trust (RPG-2014-340) and the EPSRC (EP/P010482/1). C. Si thanks the China Scholarship Council (201806890001).The synthesis of a range of brominated-Bn-containing (n = 1, 2) polycyclic aromatic hydrocarbons (PAHs) is achieved simply by reacting BBr3 with appropriately substituted alkynes via a bromoboration/electrophilic C-H borylation sequence. The brominated-Bn-PAHs were isolated as either the borinic acid or B-mesityl-protected derivatives, with the latter having extremely deep LUMOs for the B2-doped PAHs (with one example having a reduction potential of E1/2 = -0.96 V versus Fc+/Fc, Fc = ferrocene). Mechanistic studies revealed the reaction sequence proceeds by initial alkyne 1,1-bromoboration. 1,1-bromoboration also was applied to access a number of unprecedented 1-bromo-2,2-diaryl substituted vinylboronate esters direct from internal alkynes. Bromoboration/C-H borylation installs useful C-Br units onto the Bn-PAHs, which were utilised in Negishi coupling reactions, including for the installation of two triarylamine donor (D) groups onto a B2-PAH. The resultant D-A-D molecule has a low optical gap with an absorption onset at 750 nm and emission centered at 810 nm in the solid state.Publisher PDFPeer reviewe
Low coordinate NHC-Zinc-Hydride Complexes Catalyze Alkyne C-H Borylation and Hydroboration using Pinacolborane
Organozinc
compounds containing sp, sp<sup>2</sup>, and sp<sup>3</sup> CâZn
moieties undergo transmetalation with pinacolborane
(HBPin) to produce ZnâH species and organoboronate esters (RBPin).
This ZnâC/HâB metathesis step is key to enabling zinc-catalyzed
borylation reactions, and it is used in this work to develop both
terminal alkyne CâH borylation and internal alkyne hydroboration.
These two conversions can be combined in one pot to achieve the zinc-catalyzed
conversion of terminal alkynes to 1,1-diborylated alkenes without
isolation of the sensitive (to protodeboronation) alkynyl boronate
ester intermediates. Mechanistic studies involving the isolation of
intermediates, stoichiometric experiments, and DFT calculations all
support mechanisms involving organozinc species that undergo metathesis
with HBPin. Furthermore, zinc-catalyzed hydroboration can proceed
via a hydrozincation step, which does not require any exogenous catalyst
in contrast to all previously reported alkyne hydrozincations. Bulky <i>N</i>-heterocyclic carbenes (NHCs) are key for effective catalysis
as the NHC steric bulk enhances the stability of the NHCâZn
species present during catalysis and provides access to low-coordinate
(NHC)ÂZnâH cations that are electrophilic yet Brønsted
basic. This work provides an alternative approach to access synthetically
desirable pinacolâorganoboronate esters using earth-abundant
metal-based borylation catalysts
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